The door is open to Kyler Murray handling quarterback duties for the Cardinals this week. As things stand, however, it is unlikely that will be the case. 
Jacoby Brissett is expected to get the nod on Sunday, as first reported by ESPN’s Adam Schefter and Jeremy Fowler. Brissett has made a pair of appearances this season, his debut campaign in Arizona. He has yet to make a start for his latest team, though.
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Barring an unforeseen development, that will change tomorrow. Murray is still a possibility in terms of suiting up, but he was limited in practice on Friday after missing the previous two days. The former No. 1 pick’s foot ailment is a version of a Lisfranc injury, Ian Rapoport of NFL Network reports. As a result, Murray’s absence may not be limited to one game. His status will certainly be one to watch closely.
As of yesterday, the Cardinals were uncertain of their Week 6 starter; that left the team to craft plans for both Murray and Brissett. The latter is now in position to take on QB1 responsibilities for at least one week, however. Brissett has 53 starts and 83 appearances to his name. That includes a four-year spell with the Colts; Arizona will play Indianapolis in Week 6.
That Indy tenure included starting duties for two seasons. Brissett has also seen a multi-game run atop the depth chart with the Browns in 2022 while filling in for the suspended Deshaun Watson and at the start of last year before the Patriots handed the reins over to Drake Maye. The 32-year-old has not managed to post a winning record during any of his QB1 runs, but he will be counted on to keep Arizona’s offense afloat for at least one contest.
The Cardinals opened the season with two straight one-score wins, but they have lost three straight contests on game-ending field goals. Murray will be counted on to continue playing a central role in the efforts to reach the postseason when healthy, but his recovery process will determine the point at which he is back to full strength. It would come as little surprise if the Cardinals proceeded with caution in terms of his return to action given Murray’s status as their franchise passer (something all-but confirmed past the current campaign through his contract structure).
The 4-1 Colts have started out N0. 3 in the league in terms of points allowed this season. However, new DC Lou Anarumo‘s unit sits just 19th against the pass and injuries in the secondary remain a concern. That group will look to improve beginning tomorrow against a shorthanded Cardinals offense.