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Cardinals News: 4 Running Backs That Could Replace James Conner After Devastating Injury

September 21, 2025 by Last Word On Pro Football

Arizona Cardinals running back James Conner suffered a gruesome lower-body injury that will likely sideline the longtime veteran for quite some time. While we do not know the extent of the injury as of this posting, Conner never returned to the game, had to be carted off the field, and, based on nothing more than the tape, it sure didn’t look good.

Update: James Conner suffered a season-ending injury, per ESPN’s Adam Schefter

The Cardinals basically made 2024 third-round pick Trey Benson the full-time starter in Conner’s absence, but the second-year pro probably can’t handle that type of workload over an extended stretch. This team needs another running back to navigate the James Conner injury, and there should be a few veterans available for a relatively cheap price.

4 Running Backs Cardinals Could Target After James Conner Injury

James Conner Injury
Sep 21, 2025; Santa Clara, California, USA; Medical personal tend to Arizona Cardinals running back James Conner (6) during the second half against the San Francisco 49ers at Levi’s Stadium. Mandatory Credit: Kyle Terada-Imagn Images

Main Photo: Kyle Terada

The post Cardinals News: 4 Running Backs That Could Replace James Conner After Devastating Injury appeared first on Last Word on Pro Football.

Filed Under: Cardinals

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