With starting quarterback Kyler Murray dealing with a foot injury, the Cardinals are preparing for him or backup Jacoby Brissett to start in Week 6 in Indianapolis, per ESPN’s Jeremy Fowler.
Murray went down in Arizona’s Week 5 matchup with the Titans, but returned to finish the game. He then missed practice on Wednesday and Thursday, throwing his status for Sunday’s matchup with the Colts into doubt. Even if he practices Friday, he will be a “close call,” per Fowler, indicating that the Cardinals may be making a game-time decision on their starting quarterback.
During a 2-3 start for the Cardinals, Murray has completed 68.3 percent of passes for 962 yards, six touchdowns, and three interceptions.
As the dual threat continues distancing himself from the torn ACL he suffered in 2022, Murray made it clear during the offseason that he planned to run more this year. The 28-year-old has done just that, having averaged just under six rushes per game while amassing 173 yards (6.0 YPC) and a score. He posted an eye-popping 7.3 yards per rush last year during his first 17-game slate, though he did that on fewer than five attempts per contest.
With Murray relying so much on his mobility (he’s a career 3,000-yard rusher with 32 TDs on the ground), a foot injury is less than ideal and could lead the Cardinals to start Brissett on Sunday. The well-traveled veteran, 32, made the Cardinals the sixth organization of his career when he signed a two-year pact with them in the offseason.
Since debuting in 2016, Brissett has made 53 starts, including five with the Patriots in 2024. He connected on 59% of passes for 826 yards, two TDs, and a pick last year.
If Brissett plays this week, he’ll be facing one of his former teams. A Colt from 2017-20, Brissett took over as their starter when Andrew Luck abruptly retired in August 2019. The Brissett-led Colts went 7-9 that season. Six years since Luck stepped away, the Colts still haven’t found a franchise QB, though offseason free agent addition Daniel Jones has surprisingly played like one during a 4-1 start in 2025.
While Jones and the Colts are coming off a 40-6 rout of the Raiders, the Cardinals have dropped three in a row by a combined five points. They’ll hope Brissett can help turn their fortunes around if Murray is unable to play.
Connor Byrne contributed to this post.