3:32 PM: NFL Network’s Ian Rapoport tweets that Hopkins “withdrew his appeal” of the suspension, making it official that he will miss the opening six weeks of the season without pay.
3:04 PM: The Cardinals made one notable addition to their receiving corps over the weekend, but they will be starting the season without their No. 1. DeAndre Hopkins is being suspended six games for a violation of the league’s Performance Enhancing Drug policy (Twitter link via ESPN’s Adam Schefter). 
The WR room has seen some significant changes this offseason for the Cardinals. Christian Kirk left in free agency, leaving a vacancy for a starting spot at the position. The team then filled that hole with the acquisition of former Raven Marquise Brown. As Schefter notes, that transaction becomes perhaps less surprising given the news of Hopkins’ suspension.
In years past, four games was the benchmark for suspension lengths regarding PED usage. More recently, however, that number has been elevated to six – as the likes of Ryan Anderson and Corey Coleman have found out. This news extends the length of Hopkins’ overall absence, as he missed the final four games of the 2021 regular season (and the team’s playoff loss) due to injury.
That missed time led to the three-time All-Pro posting career-low totals in terms of production. Across his two seasons with the Cardinals, the 29-year-old has posted 1,979 receiving yards and 14 touchdowns. In his absence late in the year, however, Arizona’s offense continued a concerning trend of falling off considerably. The team will be in a similar situation to begin the 2022 campaign.
Hopkins becomes the second big-name wideout to receive a notable ban this offseason. Calvin Ridley will be sidelined for at least the entire 2022 campaign after he wagered on NFL games.